I'm new at this - and excited to be doing it! I've got lots of ideas! (well, today at least!) I'll start with my favorite baby advice!
Some of the best advice I got when pregnant with my first baby was not parenting advice! (I just love practical advice, don't you?) I have never forgotten the sweet lady who recommended this to me, and I highly recommend it!
You know how baby always spits up, or the diaper leaks or some kind of mess always occurs in the crib? Of course, it's always in the middle of the night when you are trying to wake up, balance the baby in one arm and change the sheets with the other! And of course, you have to take off the mobile and the crib bumper and any other fun & stimulating toy that is attached. Of course, they make these really neat things that you can tie across the bed, but that only works until they baby can't move! Here's my Works for Me! (Well, it worked for me, since I have big kids now!)
Layer the crib mattress as such: crib liner, sheet, crib liner, sheet. Then when you need to change the sheet, you just pull off the top layer and voila! You have a clean bed!